HUMAN INTERFERON REGULATORY FACTOR-I - INTRON EXON ORGANIZATION

被引:17
作者
CHA, Y
SIMS, SH
ROMINE, MF
KAUFMANN, M
DEISSEROTH, AB
机构
[1] Department of Hematology, University of Texas, M.D. Anderson Cancer Center, Houston
[2] Battelle Pacific Northwest Laboratories, K4-06, Richland, WA 99352
关键词
D O I
10.1089/dna.1992.11.605
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Interferon (IFN) regulatory factor 1 (IRF-1) is a transcriptional regulatory protein that mediates the transcriptional activation of the IFN-alpha and IFN-beta genes by viruses and IFNs. To characterize the mechanisms that govern the level of IRF-1 in cells, we isolated the IRF-1 gene and characterized the structure of its intronic and exonic domains and of its regulatory promoter region. A human placental genomic library was screened with an IRF-1 cDNA probe, and two clones that contained the IRF-1 gene and its 5' regulatory region were obtained. We used these clones to determine the complete nucleotide sequence for the IRF-1 gene, finding that the IRF-1 gene spanned 7.72 kb of DNA and included 10 exons and 9 introns. When the deduced amino acid sequences were compared among different species, the most conserved exons were exons 2, 3, and 4, in which the putative DNA binding domain for the IRF-1 protein is located.
引用
收藏
页码:605 / 611
页数:7
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