ANALYTICAL INVERSE SUPERCRITICAL-FLUID EXTRACTION OF POLAR PHARMACEUTICAL COMPOUNDS FROM CREAM AND OINTMENT MATRICES

被引：16

作者：

MOORE, WN ^{[1
]}

TAYLOR, LT ^{[1
]}

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1994年 / 12卷 / 10期

关键词：

NEOSPORIN(R); SUPERCRITICAL FLUID EXTRACTION; CREAMS AND OINTMENTS;

D O I：

10.1016/0731-7085(94)00071-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

It has been shown that inverse supercritical fluid extraction (SFE) can be used to analytically isolate a polar analyte from its matrix even at low concentrations (0.016%). Inverse SFE has been shown to be successful not only for the semi-solid Neosporin(R) ointments, but also for the semi-liquid Neosporin(R) creams as well. The technique has been shown to be superior to solid-phase extraction in both cases and affords the analytical chemist a quicker and safer method of sample preparation of analytes from both creams and ointments.

引用

页码：1227 / 1232

页数：6

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