MYC AMPLIFICATION - REGULATION OF MYC FUNCTION

被引：7

作者：

KOSKINEN, PJ

MAKELA, TP

VASTRIK, I

ALITALO, K

机构：

[1] UNIV HELSINKI, DEPT PATHOL, SF-00290 HELSINKI 29, FINLAND

[2] UNIV HELSINKI, DEPT VIROL, MOLEC CANC BIOL LAB, SF-00290 HELSINKI, FINLAND

来源：

CLINICA CHIMICA ACTA | 1993年 / 217卷 / 01期

关键词：

AMPLIFICATION; MYC ONCOGENES; TRANSCRIPTIONAL REGULATION;

D O I：

10.1016/0009-8981(93)90237-X

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The myc oncogenes have been implicated in the control of cell proliferation in both normal and neoplastic cells. There is increasing evidence that Myc proteins function as transcriptional regulators of other genes apparently involved in the control of cell proliferation. The effects of Myc on both gene expression and cell growth are differentially regulated by the recently described Max and DELTAMax proteins that can either cooperate or compete with Myc for sequence-specific DNA binding.

引用

页码：57 / 62

页数：6

共 30 条

[1] MYC-ONCOGENES - ACTIVATION AND AMPLIFICATION [J].