DNA STRAND BREAKS AND CHROMOSOMAL-ABERRATIONS INDUCED BY H2O2 AND CO-60 GAMMA-RADIATION

被引：60

作者：

RUEFF, J

BRAS, A

CRISTOVAO, L

MEXIA, J

SADACOSTA, M

PIRES, V

机构：

[1] UNIV NOVA LISBOA, FAC SCI & TECHNOL, DEPT MATH, P-1300 LISBON, PORTUGAL

[2] OSANTA MARIA HOSP, SERV RADIOL, P-1600 LISBON, PORTUGAL

来源：

MUTATION RESEARCH | 1993年 / 289卷 / 02期

关键词：

DNA BREAKAGE; CHROMOSOMAL ABERRATIONS; HUMAN BLOOD CELLS; H2O2; IONIZING RADIATION;

D O I：

10.1016/0027-5107(93)90070-V

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA strand breaks and chromosomal aberrations (CAs) were studied in human cells treated with hydrogen peroxide or with ionizing radiation. DNA strand breaks could be produced at dose levels of H2O2 much lower than those which induced CAs. Doses as low as 0.5 mM of H2O2 produced about as many DNA strand breaks as 2 Gy of Co-60 gamma-radiation. On the other hand, as much as 20 mM H2O2 produced only half as many CAs as 1 Gy of Co-60 gamma-radiation. The different mechanisms involved in the production of human genetic damage by H2O2 and gamma-radiation are discussed.

引用

页码：197 / 204

页数：8

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