THE STRUCTURAL BASIS OF THE CARCINOGENIC AND MUTAGENIC POTENTIALS OF PHYTOALEXINS

被引：2

作者：

ROSENKRANZ, HS ^{[1
]}

KLOPMAN, G ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106

来源：

MUTATION RESEARCH | 1990年 / 245卷 / 01期

关键词：

Alexins; CASE; Phytoalexins; Plant pesticides; Structural basis; Structure-activity relations;

D O I：

10.1016/0165-7992(90)90025-F

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

CASE, a structure-activity relational system, was used to predict the proportion of substances to be carcinogenic and mutagenic among plant pesticides (phytoalexins) and other natural products compared to that of randomly selected chemicals. There were no significant differences between phytoalexins and other natural products. On the other hand, the natural products, as a group, were predicted to be less mutagenic and carcinogenic than randomly selected chemicals. 37% of natural products are predicted to be rodent carcinogens. © 1990.

引用

页码：51 / 54

页数：4

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