AT LEAST 3 PROMOTERS DIRECT EXPRESSION OF THE MOUSE GLUCOCORTICOID RECEPTOR GENE

被引：139

作者：

STRAHLE, U ^{[1
]}

SCHMIDT, A ^{[1
]}

KELSEY, G ^{[1
]}

STEWART, AF ^{[1
]}

COLE, TJ ^{[1
]}

SCHMID, W ^{[1
]}

SCHUTZ, G ^{[1
]}

机构：

[1] GERMAN CANC RES CTR,INST CELL & TUMOR BIOL,NEUENHEIMER FELD 280,W-6900 HEIDELBERG 1,GERMANY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 15期

关键词：

DNASE-I HYPERSENSITIVE SITES; LYMPHOCYTES-T;

D O I：

10.1073/pnas.89.15.6731

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have characterized the gene for the mouse glucocorticoid receptor. The gene spans almost-equal-to 110 kilobases, and glucocorticoid receptor transcripts are assembled from nine exons. Expression of the gene is controlled by at least three promoters, resulting in glucocorticoid receptor transcripts with different 5' nontranslated exons. One promoter is cell-specific, found to be active only in T lymphocytes. The other two promoters are active to various degrees in all cell lines and tissues so far analyzed and are located in a CpG island. The promoter activities are accompanied by DNase I hypersensitivity sites in chromatin. In contrast to a conservation of exon-intron structure, differences in promoter organization suggest a divergence between the evolution of regulatory and coding regions among members of the steroid receptor super-family.

引用

页码：6731 / 6735

页数：5

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