C10 N-ACYL MODIFIED FK-506 - A POSSIBLE HYBRID ANALOG OF THE TRANSITION-STATE OF PEPTIDYL-PROLYL CIS-TRANS ISOMERIZATION

被引：9

作者：

DONALD, DK

COOPER, ME

FURBER, M

WELLS, E

HUTCHINSON, R

BLACK, FM

机构：

[1] Department of Medicinal Chemistry Fisons PLC Pharmaceutical Division, Loughborough, LE11 0RH, Bakewell Road

[2] Department of Biochemistry, Fisons PLC Pharmaceutical Division, Loughborough, LE11 0RH, Bakewell Road

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 10期

关键词：

D O I：

10.1016/S0040-4039(00)79671-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three C 10 N-Acyl derivatives of FK-506 have been prepared. The reduced receptor binding of these analogues is not consistent with a direct overlap of FK-506 and a peptide substrate.

引用

页码：1375 / 1378

页数：4

共 24 条

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