ELEVATED EXPRESSION OF ICAM1 (CD54) AND MINIMAL EXPRESSION OF LFA3 (CD58) IN EPSTEIN-BARR-VIRUS-POSITIVE NASOPHARYNGEAL CARCINOMA-CELLS

被引：37

作者：

BUSSON, P ^{[1
]}

ZHANG, Q ^{[1
]}

GUILLON, JM ^{[1
]}

GREGORY, CD ^{[1
]}

YOUNG, LS ^{[1
]}

CLAUSSE, B ^{[1
]}

LIPINSKI, M ^{[1
]}

RICKINSON, AB ^{[1
]}

TURSZ, T ^{[1
]}

机构：

[1] UNIV BIRMINGHAM, SCH MED, DEPT CANC STUDIES, CANC RES CAMPAIGN LABS, BIRMINGHAM B15 2TJ, W MIDLANDS, ENGLAND

来源：

INTERNATIONAL JOURNAL OF CANCER | 1992年 / 50卷 / 06期

关键词：

D O I：

10.1002/ijc.2910500605

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein-Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of tumor-infiltrating lymphocytes, NPC cells obviously escape immune surveillance directed to EBV antigens. Previous investigations carried out on EBV-positive Burkitt lymphoma (BL) cells have shown that this fact may be partially accounted for by a lack of expression of ICAM1 (CD54) and LFA3 (CD58). ICAM1 and LFA3 have therefore been investigated in fresh NPC biopsies and transplanted NPCs. With only 1 exception out of 9 cases, NPC cells appear to express high levels of ICAM1 and low levels of LFA3. This is a complete inversion of the pattern observed in normal epithelial cells in vivo. Additional investigations will be required to determine to what extent these characteristics affect T-cell interactions with NPC cells, specially in the process of EBV-antigen recognition.

引用

页码：863 / 867

页数：5

共 26 条

[1] RELATIONSHIP BETWEEN EPSTEIN-BARR VIRUS AND UNDIFFERENTIATED NASOPHARYNGEAL CARCINOMA - CORRELATED NUCLEIC-ACID HYBRIDIZATION AND HISTOPATHOLOGICAL EXAMINATION [J].