NEW CD FROM THE B-CELL SECTION OF THE 5TH-INTERNATIONAL-WORKSHOP-ON-HUMAN-LEUKOCYTE-DIFFERENTIATION-ANTIGENS

被引：46

作者：

ENGEL, P

TEDDER, TF

机构：

[1] Department of Immunology, Duke University Medical Center, Durham, NC 27710

来源：

LEUKEMIA & LYMPHOMA | 1994年 / 13卷

关键词：

CELL; CD; MONOCLONAL ANTIBODIES; DIFFERENTIATION ANTIGENS;

D O I：

10.3109/10428199409052677

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This review summaries the expression and the molecular and biochemical characteristics of eight new Clusters of Differentiation (CD79-CD86) established by the B cell Section during the Fifth International Workshop on Human Leukocyte Differentiation Antigens. CD79 monoclonal antibodies (mAb) identify the mb1 (CD79 alpha) and B29 (CD79 beta) components of the surface immunoglobulin (Ig) receptor complex. CD80 (B7/BB-1) is a costimulatory molecule that serves as the ligand for two molecules expressed on T lymphocytes, CD28 and CTLA-4. CD81 (TAPA-1) and CD82 (R2) are new members of the tetra-spans family of transmembrane proteins, which include CD9, CD37, CD53 and CD63. These proteins are postulated to be involved in signal transduction. CD83 (HB15) is a marker for human interdigitating reticulum cells, circulating dendritic cells and Langerhans cells. CDw84 and CD85 are new B cell-associated molecules that are also expressed by monocytes. CD86 is a new B cell activation antigen.

引用

页码：61 / 64

页数：4

共 29 条

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