PREVALENCE OF CIPROFLOXACIN RESISTANCE IN MULTIRESISTANT GRAM-NEGATIVE INTENSIVE-CARE UNIT ISOLATES

被引:11
作者
KHURANA, CM
WOJACK, BR
机构
[1] Dept. of Pathology, Pediatric Infectious Disease Laboratory, Illinois Masonic Medical Center, Chicago, 60657, IL
关键词
D O I
10.1007/BF01793573
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Of 107 gram-negative isolates obtained from intensive care units examined for patterns of multiresistance to 16 antimicrobial agents, 54.2% were multiresistant, defined as resistant to three or more test antimicrobials. Ciprofloxacin had excellent activity against all isolates with 93.4% susceptibility. Ciprofloxacin also performed well on multiresistant isolates with 89.7% susceptibility, which included 42.2% inducible Enterobacteriaceae. All six multiresistant ciprofloxacin-resistant isolates were resistant to five or more of the tested antimicrobials (mean 9.0), including a highly resistant Proteus mirabilis urine isolate resistant to 14 of 16 agents. The only antimicrobial to which all of the ciprofloxacin-multiresistant isolates were resistant, was ampicillin, indicating an absence of cross resistance. In addition, ciprofloxacin had excellent activity (100% susceptibility) against Enterobacter spp. and Klebsiella pneumoniae, two organisms frequently associated with nosocomial infections.
引用
收藏
页码:S99 / S104
页数:6
相关论文
共 13 条
[2]  
GILBERT DN, 1987, AM J MED, V82, P254
[3]  
HOOGKAMP-KORSTANJE J A A, 1989, Journal of Drug Development, V2, P93
[4]  
KAYSER FH, 1987, AM J MED, V82, P33
[5]  
MAPLE P, 1990, J CHEMOTHER, V5, P280
[6]   AN UPDATE ON FLUOROQUINOLONES [J].
NEU, HC .
CURRENT OPINION IN INFECTIOUS DISEASES, 1992, 5 (06) :755-763
[7]   QUINOLONE RESISTANCE - SUSCEPTIBILITY DATA FROM A 300-BED COMMUNITY-HOSPITAL [J].
PARRY, MF ;
PANZER, KB ;
YUKNA, ME .
AMERICAN JOURNAL OF MEDICINE, 1989, 87 (5A) :S12-S16
[9]   NEW BETA-LACTAMS - NEW PROBLEMS FOR THE INTERNIST [J].
SANDERS, CC .
ANNALS OF INTERNAL MEDICINE, 1991, 115 (08) :650-651
[10]  
SANDERS WE, 1988, REV INFECT DIS, V10, P830