INHIBITORY EFFECTS OF BROMOCRIPTINE ON PHOSPHOLIPID PEROXIDATION INDUCED BY DOPA AND IRON

被引：23

作者：

TANAKA, M

SOTOMATSU, A

YOSHIDA, T

HIRAI, S

机构：

[1] Department of Neurology, Gunma University School of Medicine, Maebashi, Gunma, 371, Showa-machi

来源：

NEUROSCIENCE LETTERS | 1995年 / 183卷 / 1-2期

关键词：

BROMOCRIPTINE; PARKINSONS DISEASE; LIPID PEROXIDATION; DOPA; IRON; ANTIOXIDANT;

D O I：

10.1016/0304-3940(94)11128-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Membrane lipid peroxidation has been suggested to participate in the nigral degeneration of Parkinson's disease. In the present study, we demonstrate that bromocriptine inhibits lipid peroxidation in phospholipid liposomes induced by DOPA and iron complexes. Because this lipid peroxidation is not mediated by active oxygen species, antioxidant properties of bromocriptine do not seem to be derived from radical scavenging effects in our experimental conditions. Bromocriptine had no scavenging effect on superoxide produced by hypoxanthine-xanthine oxidase when determined by the chemiluminescence assay using MCLA, a Cypridina luciferin analog, as a probe,

引用

页码：116 / 119

页数：4

共 18 条

[1] BRAIN PEROXIDASE AND CATALASE IN PARKINSON DISEASE [J].