CARBON SOURCE NUTRITION OF RAPAMYCIN BIOSYNTHESIS IN STREPTOMYCES-HYGROSCOPICUS

被引：47

作者：

KOJIMA, I ^{[1
]}

CHENG, YR ^{[1
]}

MOHAN, V ^{[1
]}

DEMAIN, AL ^{[1
]}

机构：

[1] MIT,FERMENTAT MICROBIOL LAB,CAMBRIDGE,MA 02139

来源：

JOURNAL OF INDUSTRIAL MICROBIOLOGY | 1995年 / 14卷 / 06期

关键词：

RAPAMYCIN BIOSYNTHESIS; CARBON SOURCES; NUTRITION; STREPTOMYCES HYGROSCOPICUS; IMMUNOSUPPRESSANTS; ANTIBIOTICS;

D O I：

10.1007/BF01573954

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chemically-defined media were developed for rapamycin production by Streptomyces hygroscopicus. Thirty-five carbon sources were tested for their effect on production. Eight failed to support growth and seven appeared to repress or inhibit rapamycin formation. The best combination of two carbon sources were 2% fructose and 0.5% mannose. Acetate and propionate, which are known to contribute most of the carbon atoms of the lactone ring, were unsatisfactory for growth and/or rapamycin production.

引用

页码：436 / 439

页数：4

共 13 条

[1]

BORMAN S, 1993, CHEM ENG NEWS, V24, P28

[2] CYCLOSPORIN-A AND C NEW METABOLITES FROM TRICHODERMA-POLYSPORUM (LINK EX PERS) RIFAI [J].

DREYFUSS, M ;

HARRI, E ;

HOFMANN, H ;

KOBEL, H ;

PACHE, W ;

TSCHERTER, H .

EUROPEAN JOURNAL OF APPLIED MICROBIOLOGY, 1976, 3 (02) :125-133

[3] THE STRUCTURE OF DEMETHOXYRAPAMYCIN [J].

FINDLAY, JA ;

LIU, JS ;

BURNELL, DJ ;

NAKASHIMA, TT .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1982, 60 (15) :2046-2047

[4]

MORRIS RE, 1992, TRANSPLANT REV, V16, P39

[5] THE CYCLOHEXANE MOIETY OF RAPAMYCIN IS DERIVED FROM SHIKIMIC ACID IN STREPTOMYCES-HYGROSCOPICUS [J].

PAIVA, NL ;

ROBERTS, MF ;

DEMAIN, AL .

JOURNAL OF INDUSTRIAL MICROBIOLOGY, 1993, 12 (06) :423-428

[6] THE IMMEDIATE PRECURSOR OF THE NITROGEN-CONTAINING RING OF RAPAMYCIN IS FREE PIPECOLIC ACID [J].

PAIVA, NL ;

DEMAIN, AL ;

ROBERTS, MF .

ENZYME AND MICROBIAL TECHNOLOGY, 1993, 15 (07) :581-585

[7] INCORPORATION OF ACETATE, PROPIONATE, AND METHIONINE INTO RAPAMYCIN BY STREPTOMYCES-HYGROSCOPICUS [J].

PAIVA, NL ;

DEMAIN, AL ;

ROBERTS, MF .

JOURNAL OF NATURAL PRODUCTS, 1991, 54 (01) :167-177

[8] RAPAMYCIN - A NOVEL IMMUNOSUPPRESSIVE MACROLIDE [J].

SEHGAL, SN ;

MOLNARKIMBER, K ;

OCAIN, TD ;

WEICHMAN, BM .

MEDICINAL RESEARCH REVIEWS, 1994, 14 (01) :1-22

[9]

SEHGAL SN, 1975, J ANTIBIOT, V28, P727, DOI 10.7164/antibiotics.28.727

[10]

SEHGAL SN, 1983, J ANTIBIOT, V34, P351

← 1 2 →