POLYCHLORINATED DIBENZO-P-DIOXINS (PCDDS) AND POLYCHLORINATED DIBENZOFURANS (PCDFS) IN HUMAN-MILK SAMPLES COLLECTED ACROSS CANADA IN 1986-87

被引：17

作者：

RYAN, JJ

LIZOTTE, R

PANOPIO, LG

SHEWCHUK, C

LEWIS, DA

SUN, WF

机构：

[1] Food Research Division, Bureau of Chemical Safety, Food Directorate, Health Protection Branch, Health and Welfare Canada, Ottawa

[2] Department of Chemistry, Carleton University, Ottawa, ON

来源：

FOOD ADDITIVES AND CONTAMINANTS | 1993年 / 10卷 / 04期

关键词：

PCDDS; PCDFS; HUMAN MILK; 2,3,7,8-SUBSTITUTED; TEQ; CANADA;

D O I：

10.1080/02652039309374165

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Monitoring of human milk samples for the presence of chemical contaminants has been carried out in Canada for several decades. In 1986-87 over 400 donations of human milk were collected nationwide and 100 of these, selected by province according to population, were analysed for the PCDDs/PCDFs. The results show the presence of about eleven different analytes all with 2,3,7,8-substitution with the PCDDs at higher and more variable concentrations than the PCDFs. On a 2,3,7,8-TCDD toxic equivalents (TEQ) basis, the mean value for the country is about 15 ng per kg milk fat. This TEQ value is similar to that from many other industrialized nations and about 50% lower than certain European states. Little or no variation was apparent in the milk content among the various Canadian provinces probably reflecting the uniformity of the general food supply across the country. Limited data over a period of five years suggest the average level of these compounds in human milk may be decreasing.

引用

页码：419 / 428

页数：10

共 18 条

[1]

Dewailly E., Tremblay-Rousseau H., Carrier G., Groulx S., Gingras S., Boggess K., Stanley J., Weber J.P., PCDDs, PCDFs, and PCBs in human milk of women exposed to a PCB fire and of women from the general population of Québec, Canada, Chemosphere, 23, pp. 1831-1835, (1991)

[2]

Hofvander Y., Extent and benefits of breast-feeding, Chemical Contaminants in Human Milk, pp. 1-8, (1991)

[3]

Jensen A.A., Background levels in humans, Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, pp. 345-380, (1989)

[4]

Kutz F.W., Barnes D.G., Bottimore D.P., Greim H., Bretthauer E.W., The international toxicity equivalency factor (I‐TEF) method of risk assessment for complex mixtures of dioxins and related compounds, Chemosphere, 20, pp. 751-757, (1990)

[5]

Mes J., Davies D.J., Turton D., Sun W.-F., Levels and trends of chlorinated hydrocarbon contaminants in the breast milk of Canadian women, Food Additives and Contaminants, 3, pp. 313-322, (1986)

[6]

Mes J., Davies D.J., Doucet J., Weber D., Mc Mullen E., Levels of chlorinated ydrocarbon residues in Canadian human breast milk and their relationship to some characteristics of the donors, Food Additives and Contaminants, 10, pp. 429-441, (1993)

[7]

Noren K., Lunden A., Trend studies of polychlorinated biphenyls, dibenzo-p-dioxins and dibenzofurans in human milk, Chemosphere, 23, pp. 1895-1901, (1991)

[8]

Rappe C., Bergqvist P.-A., Hansson M., Kjeller L.-O., Lindstrom G., Marklund S., Nygren M., Chemistry and analysis of polychlorinated dioxins and dibenzofurans in biological samples, Biological Mechanisms of Dioxin Action, pp. 17-25, (1984)

[9]

Ryan J.J., Panopio L.G., Lewis D.A., Weber D.F., Conacher H.B.S., PCDDs/PCDFs in 22 categories of food collected from six Canadian cities between 1985 and 1988, Organohalogen Compounds, 10Th International Meeting Dioxin 90, 1, pp. 497-500, (1990)

[10]

Ryan J.J., Panopio L.G., Lewis D.A., Weber D.F., Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in cows’ milk packaged in plastic-coated bleached paperboard containers, Journal of Agricultural and Food Chemistry, 39, pp. 218-223, (1991)

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