MODEL EXPERIMENTS FOR ACETYLATION OF THE MARINE SPONGE PURINES AGELASIMINE-A AND AGELASIMINE-B

被引：26

作者：

FUJII, T ^{[1
]}

SAITO, T ^{[1
]}

CHIKAZAWA, J ^{[1
]}

OHBA, M ^{[1
]}

DATE, T ^{[1
]}

机构：

[1] TANABE SEIYAKU CO LTD,ORGAN CHEM RES LAB,TODA 335,JAPAN

来源：

HETEROCYCLES | 1994年 / 38卷 / 04期

关键词：

D O I：

10.3987/COM-93-6640

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reactions of 7-benzyl-N6,3-dimethyladenine (1b) and 7-benzyl-1,2-dihydro-1,3-dimethyladenine (2b), selected as models for the marine sponge alkaloids agelasimine-A (1a) and agelasimine-B (2a), with acetic anhydribe in pyridine have been studied. The product from 1b was the imidazole derivative (6b), whose structure was determined by an X-ray crystallographic analysis. The product from 2b was the N6-acetyl derivative (4b). On treatment with boiling H2O, 4b gave 7-benzyl-2,3-dimethylhypoxanthine (5b) and a compound presumed to be 11.

引用

页码：733 / 738

页数：6

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