MICROBIOLOGICAL TRANSFORMATION OF FLAVONE AND ISOFLAVONE

被引：28

作者：

IBRAHIM, ARS ^{[1
]}

ABULHAJJ, YJ ^{[1
]}

机构：

[1] UNIV MINNESOTA,COLL PHARM,DEPT MED CHEM,MINNEAPOLIS,MN 55455

来源：

XENOBIOTICA | 1990年 / 20卷 / 04期

关键词：

D O I：

10.3109/00498259009046853

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Flavone and isoflavone were subjected to microbial transformation studies. Screening with 80 fungal species showed that flavone was transformed by a large number of microorganisms and in higher yields than isoflavone. 2. Large-scale fermentations of flavone followed by isolation and characterization of metabolites using spectroscopic analysis showed the formation of 4'hydroxyflavone, 3'4'dihydroxyflavone and two cleavage products identified as o-hydroxyphenyl-hydroxymethyl ketone and 1-(o-hydroxyphenyl)-1,2-ethanediol. However, fermentation of isoflavone gave only 4'hydroxyisoflavone and 3'4'dihydroxyisoflavone. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：363 / 373

页数：11

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