ANTITUMOR AGENTS .112. EMARGINATINE-B, A NOVEL POTENT CYTOTOXIC SESQUITERPENE PYRIDINE ALKALOID FROM MAYTENUS-EMARGINATA

被引：38

作者：

KUO, YH

CHEN, CH

KUO, LMY

KING, ML

WU, TS

HARUNA, M

LEE, KH

机构：

[1] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

[2] CHINESE CULTURE UNIV,SCH AGR,TAIPEI,TAIWAN

[3] NATL DEF MED CTR,SCH PHARM,TAIPEI,TAIWAN

[4] NATL CHENG KUNG UNIV,DEPT GRAD INST CHEM,TAINAN,TAIWAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1990年 / 53卷 / 02期

关键词：

D O I：

10.1021/np50068a021

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new sesquiterpene pyridine alkaloid, emarginatine Β [2] has been isolated, along with maytansine [3], from Maytenus emarginata. Emarginatine Β showed potent cytotoxicity against human KB cells (ED50 = 0.4 μg/ml). Spectral correlations established its structure as a 9-benzoate and C-8 epimer of emarginatine A [1]. The conformational aspect of the latter compound was elucidated by nmr studies, including the use of 2D-nmr techniques and difference nOe methods. © 1990, American Chemical Society. All rights reserved.

引用

页码：422 / 428

页数：7

共 13 条

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