CORTICOTROPIN-RELEASING FACTOR INHIBITION OF SUBSTANCE P-INDUCED VASCULAR LEAKAGE IN RATS - POSSIBLE SITES OF ACTION

被引：32

作者：

GAO, GC

DASHWOOD, MR

WEI, ET

机构：

[1] UNIV CALIF BERKELEY, SCH PUBL HLTH, 316 WARREN HALL, BERKELEY, CA 94720 USA

[2] HAREFIELD HOSP, THORAC & CARDIAC SURG UNIT, HAREFIELD UB9 6JH, MIDDX, ENGLAND

来源：

PEPTIDES | 1991年 / 12卷 / 03期

关键词：

CORTICOTROPIN-RELEASING FACTOR (CRF); SUBSTANCE-P; NEUROGENIC INFLAMMATION; VASCULAR LEAKAGE; MONASTRAL BLUE; TRACHEA; ESOPHAGUS; SKIN; MUSCLE; BINDING; RECEPTOR AUTORADIOGRAPHY;

D O I：

10.1016/0196-9781(91)90113-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Substance P (SP), 40-mu-g/kg SC, induced protein leakage in the skin, muscle, trachea and esophagus of the anesthetized rat as measured by Monastral blue B labeling of small blood vessels. CRF, 30-mu-g/kg SC, injected 30 min before SP, decreased the SP-induced dye leakage. To locate where CRF might act, autoradiographic studies of [I-125]-CRF binding to esophageal segments were conducted and displaceable binding of [I-125]-CRF to submucosal elements in the esophageal epithelium were revealed, suggesting that CRF acts on selective sites to reduce vascular leakage.

引用

页码：639 / 644

页数：6

共 23 条

[1] EFFECT OF PUTATIVE PEPTIDE NEUROTRANSMITTERS ON CUTANEOUS VASCULAR-PERMEABILITY IN THE RAT [J].