INHIBITION OF NEUTROPHIL CHEMOTACTIC FACTOR PRODUCTION IN COMEDONAL BACTERIA BY SUBMINIMAL INHIBITORY CONCENTRATIONS OF ERYTHROMYCIN

被引：8

作者：

AKAMATSU, H

KUROKAWA, I

NISHIJIMA, S

ASADA, Y

机构：

[1] Department of Dermatology, Kansai Medical University, Osaka

来源：

DERMATOLOGY | 1992年 / 185卷 / 01期

关键词：

ACNE; ERYTHROMYCIN; SUBMINIMAL INHIBITORY CONCENTRATIONS; NEUTROPHIL CHEMOTACTIC FACTORS; COMEDONAL BACTERIA;

D O I：

10.1159/000247401

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The effect of 1/10 minimal inhibitory concentrations (sub-MIC) of erythromycin (EM) on human neutrophil chemotactic factor production in comedonal bacteria. Propionibacterium acnes strains, Propionibacterium granulosum strains and coagulase-negative staphylococcus (CNS) strains was assayed using the Boyden chamber method. Sub-MIC of EM significantly suppressed neutrophil chemotactic factor production in all strains of P. acnes, P. granulosum and CNS. Our results suggest that sub-MIC of EM may have an anti-inflammatory action by reducing the inflammatory capacity of comedonal bacteria in inflammatory acne.

引用

页码：41 / 43

页数：3

共 12 条

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