INSULIN RESISTANCE SYNDROME - DEFECTIVE GABA NEUROMODULATION AS A POSSIBLE HEREDITARY PATHOGENETIC FACTOR (THE GABA HYPOTHESIS)

被引：10

作者：

BLASI, C

JEANRENAUD, B

机构：

[1] Laboratoires de Recherches Métaboliques, Université de Genéve, 1211 Genéve 4, 64, Avenue de la Roseraie

来源：

MEDICAL HYPOTHESES | 1993年 / 40卷 / 04期

关键词：

D O I：

10.1016/0306-9877(93)90041-N

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The origin of the insulin resistance syndrome which, mostly through its cardiovascular implications, is characterized by a high incidence of death, is still practically unknown. Energy and glucose homeostasis are under the control of CNS centers and the neurotransmitter GABA modulates the activity of these centers. Alteration of the biochemical structure of GABA receptors is suggested as an interpretation of the origin of the syndrome.

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页码：197 / 206

页数：10

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