TRANSCATHETER ARTERIAL EMBOLIZATION AS A METHOD OF CISPLATIN-RETENTION ENHANCEMENT ON THE VX2 TUMOR UTERUS TRANSPLANTS

被引：5

作者：

HARIMA, K

HARIMA, Y

HASEGAWA, T

TANAKA, Y

机构：

[1] Department of Radiology, Kansai Medical University, Moriguchi City, Osaka, 570, 1-Banchi, Fumizono-cho

[2] Department of Science and Radiological Technology, Suzuka University of Medical Science and Technology, Mie

来源：

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY | 1995年 / 18卷 / 01期

关键词：

RABBIT; VX2 UTERINE CANCER; EMBOLIZATION; CISPLATIN; TISSUE CONCENTRATION;

D O I：

10.1007/BF02807352

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: Enhanced cisplatin (Pt) retention using transcatheter arterial chemoembolization (TAE) with Gelfoam particles was studied in rabbit uterine tumors. Methods: Ten rabbit uteri were inoculated with 5 X 10(7) cells of VX2 carcinoma. Three to four weeks later cisplatin, 1 mg/kg, was injected, either with (TAE group) or without (IA group) being mixed with small Gelfoam particles, into the aortic bifurcation over 5 s. Blood and tissue concentration of cisplatin were determined. Results: Slower arterial blood clearance of Pt was observed in the TAE group compared with the IA group, whereas the venous blood Pt clearance curves were similar for both groups. The uterine tumor Pt concentration at 80 min was found to be 2.52-fold higher after TAE compared with LA (p < 0.01). In the pelvic metastatic lymph nodes, the Pt concentration was 4.63 times higher after TAE than after IA (p < 0.01). Conclusion: These data indicate that TAE is an effective means of increasing tissue concentration in uterine tumors.

引用

页码：30 / 34

页数：5

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