VERSATILE SYNTHESIS OF AN INTERMEDIATE FOR THE 1-BETA-METHYLCARBAPENEM SYNTHESIS

被引：19

作者：

HIRAI, K

IWANO, Y

MIKOSHIBA, I

KOYAMA, H

NISHI, T

机构：

[1] New Lead Res. Lab., Med. Chem. Lab. Sankyo Co. Ltd., Shinagawa-ku, Tokyo, 140

来源：

HETEROCYCLES | 1994年 / 38卷 / 02期

关键词：

D O I：

10.3987/COM-93-6603

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A 1 beta-Methylcarboxylate (1) which is a requisite intermediate for the synthesis of the 1 beta-methylcarbapenem was obtained in an efficient manner by the coupling reaction of a Z(O)-pyridylthiosilyl enol ether and a 4-acetoxyazetidinone derivative in the presence of ZnCl2 in CH2Cl2. The reactive silyl enol ether was prepared by the reverse addition method in high yield.

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页码：277 / 280

页数：4

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