HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF EVODIAMINE IN RAT PLASMA - APPLICATION TO PHARMACOKINETIC STUDIES

被引：27

作者：

JENG, KF

LIN, YH

LIN, LC

CHOU, CJ

TSAI, TH

CHEN, CF

机构：

[1] NATL YANG MING UNIV,INST PHARMACOL,TAIPEI 11221,TAIWAN

[2] NATL RES INST CHINESE MED,TAIPEI 11221,TAIWAN

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 668卷 / 02期

关键词：

D O I：

10.1016/0378-4347(95)00090-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A previously published simple and sensitive high-performance liquid chromatographic method for determination and identification of rutaecarpine in rat plasma was used for evodiamine determination. However, the ultraviolet detection was not 344 nm, but 227 nm. The method was applied to a pharmacokinetic study of evodiamine in rats after 2 mg/kg intravenous administration. A biphasic phenomenon with a rapid distribution followed by a slower elimination phase was observed from the plasma concentration-time curve. Compartmental analysis yielded a two-compartment model.

引用

页码：343 / 345

页数：3

共 10 条

[1] THE VASORELAXANT EFFECT OF EVODIAMINE IN RAT ISOLATED MESENTERIC-ARTERIES - MODE OF ACTION [J].