EFFECT OF TRIACETIN AND POLYETHYLENE GLYCOL-400 ON SOME PHYSICAL-PROPERTIES OF HYDROXYPROPYL METHYLCELLULOSE FREE FILMS

被引：33

作者：

JOHNSON, K

HATHAWAY, R

LEUNG, P

FRANZ, R

机构：

[1] Glaxo, Inc., Pharmaceutical Development, Research Triangle Park

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 73卷 / 03期

关键词：

HYDROXYLPROPYL METHYLCELLULOSE; PLASTICIZER; GLASS TRANSITION; WATER PERMEATION; DYNAMIC MECHANICAL THERMAL ANALYSIS; THERMAL MECHANICAL ANALYSIS; AQUEOUS FILM COATING; MECHANICAL PROPERTIES;

D O I：

10.1016/0378-5173(91)90412-H

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Free film techniques were used to study the effect of two plasticizers with different aqueous solubilities, triacetin and polyethylene glycol 400 (PEG 400), on the properties of hydroxypropyl methylcellulose (HPMC) free films cast from aqueous solutions. Thermomechanical and mechanical analysis of the films demonstrated that both additives were effective plasticizers for HPMC. PEG 400 was found to enhance water vapor permeability of the free films while triacetin slightly decreased water vapor permeability. Furthermore, triacetin significantly reduced the amount of water absorbed by HPMC films while PEG 400 had no significant effect. The results of these studies can be useful for designing soluble aqueous film coating systems when one or more of the tablet components is sensitive to water.

引用

页码：197 / 208

页数：12

共 30 条

[1] THE MECHANICAL-PROPERTIES OF HYDROXYPROPYLMETHYLCELLULOSE FILMS DERIVED FROM AQUEOUS SYSTEMS .1. THE INFLUENCE OF PLASTICIZERS [J].