PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE-C ACTIVITY IN THE POSTMORTEM HUMAN BRAIN - NO ALTERATION IN ALZHEIMERS-DISEASE

被引：30

作者：

SHIMOHAMA, S

FUJIMOTO, S

TANIGUCHI, T

KIMURA, J

机构：

[1] KYOTO PHARMACEUT UNIV,DEPT BIOCHEM,KYOTO 607,JAPAN

[2] KYOTO PHARMACEUT UNIV,DEPT NEUROBIOL,KYOTO 607,JAPAN

来源：

BRAIN RESEARCH | 1992年 / 579卷 / 02期

关键词：

PHOSPHOLIPASE-C; PHOSPHATIDYLINOSITOL; ACTIVITY; HUMAN BRAIN; ALZHEIMERS DISEASE; POSTMORTEM STABILITY;

D O I：

10.1016/0006-8993(92)90073-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The activity of phospholipase C (PLC) which hydrolyzes exogenous phosphatidylinositol (PI), was investigated in samples prepared from postmortem normal human brains and Alzheimer disease brains. The enzyme activity did not change significantly after rat brains were left for 24 h at room temperature. The PI-specific PLC activity in the Alzheimer cytosolic and particulate fractions was not significantly different from that in the control fractions. The PI-specific PLC activity as a function of the free Ca2+ concentration was also similar between control and Alzheimer brains. These results suggest that the PI-specific PLC activity is not altered in Alzheimer's disease.

引用

页码：347 / 349

页数：3

共 18 条

[1] INOSITOL TRISPHOSPHATE, A NOVEL 2ND MESSENGER IN CELLULAR SIGNAL TRANSDUCTION [J].