HUMAN PITUITARY-TUMORS - STUDIES ON GENES EXPRESSION

被引:8
作者
CHERNAVSKY, AC [1 ]
CHERVIN, A [1 ]
VITALE, M [1 ]
BASSO, A [1 ]
BURDMAN, JA [1 ]
机构
[1] SANATORIO GUEMES HOSP PRIVADO,INST NEUROCIENCIAS,FCO ACUNA FIGUEROA 1240,3ER SUBSUELO,BUENOS AIRES,ARGENTINA
关键词
PITUITARY TUMORS; MESSENGER RNA; PROLACTIN; GROWTH HORMONE; C-MYC; C-FOS;
D O I
10.1080/01616412.1993.11740099
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Searching for differences in gene expression between different types of human pituitary adenomas, we evaluated the concentration of mRNA from hormonal genes (prolactin and growth hormone) and oncogenes (c-myc and c-fos) in 12 growth hormone-secreting 7 prolactin-secreting and 11 nonsecreting adenomas. We found a positive correlation between clinical diagnoses and hormonal gene expression in all the cases. Our reports indicate the presence of c-myc and c-fos mRNA in all the adenomas evaluated. The concentration of c-myc mRNA was higher in somatotrophic adenomas than in prolactinomas and nonsecreting adenomas whereas c-fos mRNA concentration was similar in the different types of tumours analysed. Oncogenes products, in tum, might stimulate DNA synthesis and cell proliferation and eventually lead to the formation of pituitary adenomas. This is a working hypothesis.
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页码:2 / 6
页数:5
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