A HUMAN RHEUMATOID-FACTOR C304 SHARES V-H AND V-L GENE USAGE WITH ANTIBODIES SPECIFIC FOR UBIQUITOUS HUMAN VIRAL

被引：9

作者：

RIOUX, JD ^{[1
]}

RAUCH, J ^{[1
]}

SILVESTRI, L ^{[1
]}

NEWKIRK, MM ^{[1
]}

机构：

[1] MCGILL UNIV,MONTREAL GEN HOSP,RES INST,DEPT MED,DIV RHEUMATOL,MONTREAL H3G 1A4,PQ,CANADA

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1994年 / 40卷 / 03期

关键词：

D O I：

10.1111/j.1365-3083.1994.tb03472.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Analysis of the variable region gene sequences of a human hybridoma rheumatoid factor (RF), derived from a patient with rheumatoid arthritis (RA), revealed the expression of genes from the V lambda I and V(H)3 families. Specifically, the C304 RF had rearranged the DPL8/Hum1v1042 and VH26 germline V-L and V-H genes, respectively. This gene usage has been observed in the rearrangement of human anti-viral antibodies specific for the herpes group of viruses. This overlap between the autoimmune and anti-viral antibody gene repertoires suggests a possible structural relationship between the immune response directed against ubiquitous pathogens and the induction of RF production.

引用

页码：350 / 354

页数：5

共 35 条

[1] THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].

ARNETT, FC ;

EDWORTHY, SM ;

BLOCH, DA ;

MCSHANE, DJ ;

FRIES, JF ;

COOPER, NS ;

HEALEY, LA ;

KAPLAN, SR ;

LIANG, MH ;

LUTHRA, HS ;

MEDSGER, TA ;

MITCHELL, DM ;

NEUSTADT, DH ;

PINALS, RS ;

SCHALLER, JG ;

SHARP, JT ;

WILDER, RL ;

HUNDER, GG .

ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324

[2] THE USE OF CHROMOSOMAL TRANSLOCATIONS TO STUDY HUMAN-IMMUNOGLOBULIN GENE ORGANIZATION - MAPPING DH SEGMENTS WITHIN 35 KB OF THE C-MU GENE AND IDENTIFICATION OF A NEW DH LOCUS [J].

BULUWELA, L ;

ALBERTSON, DG ;

SHERRINGTON, P ;

RABBITTS, PH ;

SPURR, N ;

RABBITTS, TH .

EMBO JOURNAL, 1988, 7 (07) :2003-2010

[3] A 16/6 IDIOTYPE POSITIVE ANTI-DNA ANTIBODY IS ENCODED BY A CONSERVED VH GENE WITH NO SOMATIC MUTATION [J].

CHEN, PP ;

LIU, MF ;

SINHA, SM ;

CARSON, DA .

ARTHRITIS AND RHEUMATISM, 1988, 31 (11) :1429-1431

[4] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[5] MECHANISMS THAT GENERATE HUMAN-IMMUNOGLOBULIN DIVERSITY OPERATE FROM THE 8TH WEEK OF GESTATION IN FETAL LIVER [J].

CUISINIER, AM ;

GAUTHIER, L ;

BOUBLI, L ;

FOUGEREAU, M ;

TONNELLE, C .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (01) :110-118

[6] MOLECULAR CHARACTERIZATION OF THE HUMAN IMMUNOGLOBULIN-V-GAMMA-I GERMLINE GENE REPERTOIRE [J].

DALEY, MD ;

OLEE, T ;

PENG, HQ ;

SOTOGIL, RW ;

CHEN, PP ;

SIMINOVITCH, KA .

MOLECULAR IMMUNOLOGY, 1992, 29 (09) :1031-1042

[7] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX [J].

DEVEREUX, J ;

HAEBERLI, P ;

SMITHIES, O .

NUCLEIC ACIDS RESEARCH, 1984, 12 (01) :387-395

[8] SYNOVIAL LYMPHOCYTES CAN INDICATE SPECIFIC MICROBIOLOGIC CAUSES OF RHEUMATOID-ARTHRITIS [J].

FORD, DK .

ARTHRITIS AND RHEUMATISM, 1993, 36 (10) :1350-1352

[9] MEASUREMENTS OF THE TRUE AFFINITY CONSTANT IN SOLUTION OF ANTIGEN-ANTIBODY COMPLEXES BY ENZYME-LINKED IMMUNOSORBENT-ASSAY [J].

FRIGUET, B ;

CHAFFOTTE, AF ;

DJAVADIOHANIANCE, L ;

GOLDBERG, ME .

JOURNAL OF IMMUNOLOGICAL METHODS, 1985, 77 (02) :305-319

[10]

HILLSON JL, 1992, J IMMUNOL, V149, P3741

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