THE TETRATRICOPEPTIDE REPEATS OF SSN6 INTERACT WITH THE HOMEO DOMAIN OF ALPHA-2

被引：85

作者：

SMITH, RL ^{[1
]}

REDD, MJ ^{[1
]}

JOHNSON, AD ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MICROBIOL & IMMUNOL,SAN FRANCISCO,CA 94143

来源：

GENES & DEVELOPMENT | 1995年 / 9卷 / 23期

关键词：

TETRATRICOPEPTIDE REPEAT; HOMEO DOMAIN; SSN6; ALPHA-2; TRANSCRIPTIONAL REPRESSION; REPEATED AMINO ACID MOTIF;

D O I：

10.1101/gad.9.23.2903

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The tetratricopeptide repeat (TPR) is a 34-amino-acid degenerate sequence motif that is found in a large variety of proteins, both prokaryotic and eukaryotic. TPRs are usually found in tandem arrays of up to 16 copies. In this paper we identify a direct interaction between the TPRs of Ssn6, a general transcriptional repressor, and alpha 2, a cell-type regulator in Saccharomyces cerevisiae. Five of the Ssn6 TPRs were tested individually, and all were found to interact specifically with alpha 2. These results suggest a model for TPR-protein interactions and for the role that a tandem array of TPRs may have in mediating transcriptional repression.

引用

页码：2903 / 2910

页数：8

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