FLOW-INJECTION CHEMILUMINOMETRIC DETERMINATION OF FOLIC-ACID IN PHARMACEUTICAL FORMULATIONS

被引：46

作者：

ALWARTHAN, AA

机构：

[1] Chemistry Department, College of Science, King Sand University, Riyadh-11451

来源：

ANALYTICAL SCIENCES | 1994年 / 10卷 / 06期

关键词：

CHEMILUMINESCENCE; FOLIC ACID; PHARMACEUTICAL PREPARATION; FLOW INJECTION;

D O I：

10.2116/analsci.10.919

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A continuous flow chemiluminometric method for determining 10(-8)-10(-5) M of folic acid in pharmaceutical formulations is described. The method is based on the chemiluminescence (CL) produced by the action of cerium(IV) on folic acid in an acidic medium. The emission intensity is greatly enhanced when Rhodamine B is used as a sensitizer. The procedure is automated, requires no sample pretreatment and solutions can be analyzed at a rate of 180 samples h(-1) with a relative standard deviation of 0.54% at 1.1X10(-5) M folic acid (n=10).

引用

页码：919 / 922

页数：4

共 21 条

[1]

Al-Shammary F. J., 1990, ANAL PROFILES DRUG S, V19, P221

[2] DETERMINATION OF ASCORBIC-ACID BY FLOW-INJECTION WITH CHEMILUMINESCENCE DETECTION [J].