DECREASED SENSITIVITY OF AORTA FROM HYPERTENSIVE RATS TO VASORELAXATION BY TYRPHOSTIN

被引：7

作者：

SAURO, MD

THOMAS, B

机构：

[1] Department of Immunology and Molecular Biology, Masonic Medical Research Laboratory Utica

来源：

LIFE SCIENCES | 1993年 / 53卷 / 22期

关键词：

D O I：

10.1016/0024-3205(93)90212-L

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The role of protein tyrosine kinases (PTKs) in vascular smooth muscle (VSM) contraction was examined in spontaneously hypertensive rats (SHRs). Aorta from SHRs was hyperresponsive to PTK-mediated contraction relative to normotensive Wistar-Kyoto rats (WKYs). Aorta from SHR was also hyporesponsive to vasorelaxation by tyrphostin, a selective inhibitor of PTKs. Further, we found alterations in PTK activity in aorta from SHRs. PDGF stimulated PTK activity to a greater extent in the SHR. Tryphostin inhibited PDGF-induced PTK stimulation in both strains, however, activity returned to basal levels in the WKY only. The results suggest that PTKs may be involved in VSM contraction and in the development of hypertension.

引用

收藏

页码：PL371 / PL376

页数：6

相关论文

共 15 条

[1] VASOCONSTRICTION - A NEW ACTIVITY FOR PLATELET-DERIVED GROWTH-FACTOR [J].

BERK, BC ;

ALEXANDER, RW ;

BROCK, TA ;

GIMBRONE, MA ;

WEBB, RC .

SCIENCE, 1986, 232 (4746) :87-90

[2] TYRPHOSTINS INHIBIT PDGF-INDUCED DNA-SYNTHESIS AND ASSOCIATED EARLY EVENTS IN SMOOTH-MUSCLE CELLS [J].

BILDER, GE ;

KRAWIEC, JA ;

MCVETY, K ;

GAZIT, A ;

GILON, C ;

LYALL, R ;

ZILBERSTEIN, A ;

LEVITZKI, A ;

PERRONE, MH ;

SCHREIBER, AB .

AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (04) :C721-C730

[3]

BOHR DF, 1991, HYPERTENSION, V18, pS69

[4] PROTEIN-KINASE INHIBITORS AND BLOOD-PRESSURE CONTROL IN SPONTANEOUSLY HYPERTENSIVE RATS [J].

BUCHHOLZ, RA ;

DUNDORE, RL ;

CUMISKEY, WR ;

HARRIS, AL ;

SILVER, PJ .

HYPERTENSION, 1991, 17 (01) :91-100

[5] TYRPHOSTINS .1. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF PROTEIN TYROSINE KINASE INHIBITORS [J].

GAZIT, A ;

YAISH, P ;

GILON, C ;

LEVITZKI, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (10) :2344-2352

[6] TYRPHOSTINS AS MOLECULAR TOOLS AND POTENTIAL ANTIPROLIFERATIVE DRUGS [J].

LEVITZKI, A ;

GILON, C .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (05) :171-174

[7] AN APPROACH TO THE EXPLANATION OF CELL-MEMBRANE ALTERATION IN PRIMARY HYPERTENSION [J].

POSTNOV, YV .

HYPERTENSION, 1990, 15 (03) :332-337

[8] THE PATHOGENESIS OF ATHEROSCLEROSIS - AN UPDATE [J].

ROSS, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (08) :488-500

[9] DECREASED SENSITIVITY OF SPONTANEOUSLY HYPERTENSIVE RAT AORTIC SMOOTH-MUSCLE TO VASORELAXATION BY ATRIOPEPTIN-III [J].

SAURO, MD ;

FITZPATRICK, DF .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 146 (01) :80-86

[10] DEFECTIVE CYCLIC-GMP ACCUMULATION IN SPONTANEOUSLY HYPERTENSIVE RAT AORTA IN RESPONSE TO ATRIAL NATRIURETIC FACTOR [J].

SAURO, MD ;

FITZPATRICK, DF ;

COFFEY, RG .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (11) :2109-2112