PHYSICAL LOCALIZATION OF 70 POLYMORPHIC MARKERS TO HUMAN CHROMOSOME-5 BY FLUORESCENCE INSITU HYBRIDIZATION

被引：6

作者：

NEUMAN, WL

WESTBROOK, CA

DIXON, M

ESPINOSA, R

PATEL, YD

NAKAMURA, Y

WEIFFENBACH, B

LEBEAU, MM

机构：

[1] UNIV CHICAGO,DEPT MED,HEMATOL ONCOL SECT,5841 S MARYLAND AVE,MC2115,CHICAGO,IL 60637

[2] UNIV MANCHESTER,MANCHESTER M13 9PL,LANCS,ENGLAND

[3] JAPANESE FDN CANC RES,INST CANC,DIV BIOCHEM,TOKYO 170,JAPAN

[4] COLLABORAT RES INC,WALTHAM,MA

来源：

CYTOGENETICS AND CELL GENETICS | 1993年 / 62卷 / 04期

关键词：

D O I：

10.1159/000133477

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We used fluorescence in situ hybridization (FISH) to prepare a cytogenetic framework map of 21 polymorphic markers that had been used previously to construct a genetic linkage anchor map of chromosome 5. In addition, we localized 49 other markers that have been genotyped on CEPH families. This study demonstrates that FISH can be used to confirm genetic linkage data, and that it can provide a means of determining the cytogenetic locations and relative order of markers whose order could not be assigned by genetic linkage analysis alone. The cytogenetic map prepared by FISH may help to identify probes of interest for regional mapping studies.

引用

页码：207 / 210

页数：4

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