DIAGNOSTIC USE OF MICROSATELLITE INSTABILITY IN HEREDITARY NONPOLYPOSIS COLORECTAL-CANCER

被引：84

作者：

JASS, JR ^{[1
]}

COTTIER, DS ^{[1
]}

JEEVARATNAM, P ^{[1
]}

POKOS, V ^{[1
]}

HOLDAWAY, KM ^{[1
]}

BOWDEN, ML ^{[1
]}

VANDEWATER, NS ^{[1
]}

BROWETT, PJ ^{[1
]}

机构：

[1] UNIV AUCKLAND,SCH MED,DEPT MOLEC MED,AUCKLAND,NEW ZEALAND

来源：

LANCET | 1995年 / 346卷 / 8984期

关键词：

D O I：

10.1016/S0140-6736(95)92902-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

50 families with a history of colorectal cancer were divided according to whether criteria for hereditary non-polyposis colorectal cancer (HNPCC) were fulfilled totally (A, n=19) or partly (B, n=31) and stratified by the demonstration that at least half the cancers tested per family were positive for DNA replication errors (RER+). Accepted clinical and pathological characteristics of HNPCC were found to cluster within 12 A/RER+ families in which the mean number of affected individuals per family was 10 . 1. Reliance upon clinical data alone may result in over-diagnosis of HNPCC, in small families who just meet the minimum criteria, whereas underdiagnosis is rare. The criteria could be refined by inclusion of RER status.

引用

页码：1200 / 1201

页数：2

共 11 条

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