FLUOROCARBONS AS BLOOD SUBSTITUTES - CRITICAL SOLUTION TEMPERATURES OF SOME PERFLUOROCARBONS AND THEIR MIXTURES

The exhalation of perfluorocarbons (PFCs) from the organism after administration of perfluorocarbon-based blood substitutes is discussed in terms of their lipid solubilities, which may be correlated with their critical solution temperatures (CSTs) with n-hexane, of which a number of measurements are reported here. The critical solution temperatures of some binary mixtures of PFCs with n-hexane are also reported. These are linearly dependent on the compositions of the mixtures of perfluorocarbons. The application of this simple relationship enables the extrapolation of the CST of the pure component (such as perfluoro-n-octyl bromide) for which the CST may not otherwise be easily determined. The observed CSTs of derivatives of PFCs, in which a fluorine atom has been replaced by a more polarizable atom, are strongly dependent upon the respective molar refraction.