MUTAGENIC AND TOXIC ACTIVITY OF SOME JORDANIAN MEDICINAL-PLANTS

被引：7

作者：

ALKOFAHI, A

ALKHALIL, S

机构：

[1] JORDAN UNIV SCI & TECHNOL, FAC PHARM, DEPT MED CHEM & PHARMACOGNOSY, IRBID, JORDAN

[2] UNIV JORDAN, FAC PHARM, DEPT NAT PROD, AMMAN, JORDAN

来源：

INTERNATIONAL JOURNAL OF PHARMACOGNOSY | 1995年 / 33卷 / 01期

关键词：

PLANT EXTRACTS; BRINE SHRIMP; CYTOTOXICITY; MUTAGENICITY;

D O I：

10.3109/13880209509088149

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A total of 39 ethanol extracts of Jordanian plants were examined for cytotoxicity and mutagenicity. Among the tested plants, 8 extracts were active in the brine shrimp cytotoxicity bioassay with LC(50) values in the range of 2.5-870 mu g/ml. These positive extracts were further rested for their antirumor activity on human tumor cell lines in culture. Eminium spiculatum showed activity against a lung carcinoma line (A-549) with art ED(50) of 0.0793 mu g/ml. Regarding mutagenic effect, 16 of the extracts were active on Salmonella typhim-urium strains TA98 or TA102, and the extract of Podonosma oriantalis showed mutagenic activity in both strains.

引用

页码：61 / 64

页数：4

共 14 条

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