PENETRATION OF THE BLOOD-BRAIN-BARRIER - ENHANCEMENT OF DRUG-DELIVERY AND IMAGING BY BACTERIAL GLYCOPEPTIDES

被引：29

作者：

SPELLERBERG, B

PRASAD, S

CABELLOS, C

BURROUGHS, M

CAHILL, P

TUOMANEN, E

机构：

[1] ROCKEFELLER UNIV,MOLEC INFECT DIS LAB,NEW YORK,NY 10021

[2] CORNELL UNIV,MED CTR,NEW YORK HOSP,DEPT RADIOL,NEW YORK,NY 10021

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1995年 / 182卷 / 04期

关键词：

D O I：

10.1084/jem.182.4.1037

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The blood-brain barrier restricts the passage of many pharmacological agents into the brain parenchyma. Bacterial glycopeptides induce enhanced blood-brain barrier permeability when they are present in the subarachnoid space during meningitis. By presenting such glycopeptides intravenously, blood-brain barrier permeability in rabbits was enhanced in a reversible time- and dose-dependent manner to agents less than or equal to 20 kD in size. Therapeutic application of this bioactivity was evident as enhanced penetration of the antibiotic penicillin and the magnetic resonance imaging contrast agent gadolinium-diethylene-triamine-pentaacetic acid into the brain parenchyma.

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页码：1037 / 1043

页数：7

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