INVITRO STUDIES OF THE METABOLISM OF ATRAZINE, SIMAZINE, AND TERBUTRYN IN SEVERAL VERTEBRATE SPECIES

被引：62

作者：

ADAMS, NH ^{[1
]}

LEVI, PE ^{[1
]}

HODGSON, E ^{[1
]}

机构：

[1] N CAROLINA STATE UNIV,DEPT TOXICOL,BOX 7633,RALEIGH,NC 27695

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1990年 / 38卷 / 06期

关键词：

D O I：

10.1021/jf00096a025

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The metabolism of three triazine herbicides (atrazine, simazine, and terbutryn) was studied in rat (Sprague-Dawley and Fischer strains), mouse, goat, sheep, pig, rabbit, and chicken by using in vitro hepatic 10000g supernatant or microsomal systems. Principal phase I metabolites were 4- or 6-monodealkylated-s-triazines; several observations, including studies with purified enzymes, demonstrated that phase I reactions were cytochrome P-450 mediated. There were species-related variations in rates of metabolism and in ratios of primary metabolites, although no strain-or sex-related differences were noted. Phase II products were glutathione conjugates of the parent compound and of the two monodealkylated products. Experiments with Fenton’s reagent, which generates hydroxyl radicals, gave dealkylated 2-chloro-s-triazine, supporting the possible role of active oxygen radicals in the cytochrome P-450 mediated reactions. © 1990, American Chemical Society. All rights reserved.

引用

页码：1411 / 1417

页数：7

共 23 条

[1]

BOHME C., 1967, FOOD COSMET TOXICOL, V5, P23, DOI 10.1016/S0015-6264(67)82882-7

[2] DETERMINATION OF URINARY RESIDUE LEVELS OF THE N-DEALKYL METABOLITES OF TRIAZINE HERBICIDES [J].

BRADWAY, DE ;

MOSEMAN, RF .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1982, 30 (02) :244-247

[3]

CRAYFORD JV, 1972, PESTIC BIOCHEM PHYS, V2, P295, DOI 10.1016/0048-3575(72)90033-8

[4] INVITRO METABOLISM OF ATRAZINE BY RAT-LIVER [J].

DAUTERMAN, WC ;

MUECKE, W .

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 1974, 4 (02) :212-219

[5] DETERMINATION OF S-TRIAZINE HERBICIDE RESIDUES IN URINE - STUDIES OF EXCRETION AND METABOLISM IN SWINE AS A MODEL TO HUMAN METABOLISM [J].

ERICKSON, MD ;

FRANK, CW ;

MORGAN, DP .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1979, 27 (04) :743-746

[6]

Fenton HJH., 1984, J CHEM SOC T, V65, P899, DOI DOI 10.1039/CT8946500899

[7] STUDIES ON A GLUTATHIONE S-TRANSFERASE PREPARATION FROM MOUSE-LIVER WHICH CONJUGATES CHLORO-S-TRIAZINE HERBICIDES [J].

GUDDEWAR, MB ;

DAUTERMAN, WC .

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 1979, 12 (01) :1-9

[8]

GUENGERICH FP, 1987, MAMMALIAN CYTOCHROME, V2

[9]

HODGSON E, 1980, INTRO BIOCH TOXICOLO

[10]

INGELMANSUNDBER.M, 1982, CYTOCHROME P450 BIOC

← 1 2 3 →