SYNTHESIS OF THE MONOFLUORO KETONE PEPTIDE ISOSTERE

被引：30

作者：

GARRETT, GS ^{[1
]}

EMGE, TJ ^{[1
]}

LEE, SC ^{[1
]}

FISCHER, EM ^{[1
]}

DYEHOUSE, K ^{[1
]}

MCIVER, JM ^{[1
]}

机构：

[1] PROCTER & GAMBLE CO,DIV CORP RES,MIAMI VALLEY LABS,CINCINNATI,OH 45239

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 16期

关键词：

D O I：

10.1021/jo00016a004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic method for the construction of monofluoro ketone peptide isosteres has been realized. The methodology has been employed in a synthesis of the fluoro ketone replacement for the natural substrate for D,D-carboxypeptidase-transpeptidase.

引用

页码：4823 / 4826

页数：4

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