SUSCEPTIBILITIES OF MYCOPLASMA-HOMINIS AND UREAPLASMA-UREALYTICUM TO 2 NEW QUINOLONES, SPARFLOXACIN AND WIN-57273

Mycoplasma hominis was highly susceptible to two new quinolones, with MICs for 90% of isolates tested of 0.004-mu-g/ml for WIN 57273 and 0.063-mu-g/ml for sparfloxacin, which were activities much greater than the 1-mu-g/ml found for ofloxacin and tetracycline. Although Ureaplasma urealyticum was less susceptible, the MICs for 90% of isolates tested of 0.25-mu-g/ml for WIN 57273 and 0.5-mu-g/ml for sparfloxacin were four- to eightfold greater than those found for ofloxacin (2-mu-g/ml) and tetracycline (2-mu-g/ml). The finding that U. urealyticum and M. hominis are more susceptible to WIN 57273 and sparfloxacin than they are to other quinolones suggests that these quinolones may be therapeutically useful.