EVIDENCE FOR A ROLE OF NEOSYNTHETIZED PUTRESCINE IN THE INCREASE OF GLIAL FIBRILLARY ACIDIC PROTEIN IMMUNOREACTIVITY INDUCED BY A MECHANICAL LESION IN THE RAT-BRAIN

被引：30

作者：

ZINI, I

ZOLI, M

GRIMALDI, R

PICH, EM

BIAGINI, G

FUXE, K

AGNATI, LF

机构：

[1] UNIV MODENA,IST FISIOL UMANA,VIA CAMPI 287,I-41100 MODENA,ITALY

[2] KAROLINSKA INST,DEPT HISTOL & NEUROBIOL,S-10401 STOCKHOLM 60,SWEDEN

来源：

NEUROSCIENCE LETTERS | 1990年 / 120卷 / 01期

关键词：

Astroglial reaction; Glial fibrillary acidic protein; Mechanical lesion; Polyamine; Rat; Striatum;

D O I：

10.1016/0304-3940(90)90156-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of α-difluoromethylornithine (α-DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC) the rate limiting enzyme of polyamine biosynthesis, was studied on the astroglial reaction in a model of mechanical brain injury. α-DFMO markedly decreased the astroglial activation induced by the microdialysis probe implantation in the striatum of the male rat, as studied by glial fibrillary acidic protein (GFAP) immunocytochemistry. This response was restored by putrescine (20 nmol/ml) administered via the microdialysis probe. These results suggest that the astroglial reaction and the polyamine biosynthesis activation induced by a localized mechanical lesion are causally linked phenomena. © 1990.

引用

页码：13 / 16

页数：4

共 20 条

[1] STRIATAL ORNITHINE DECARBOXYLASE ACTIVITY FOLLOWING NEUROTOXIC AND MECHANICAL LESIONS OF THE MESOSTRIATAL DOPAMINE SYSTEM OF THE MALE-RAT [J].