IDENTIFICATION OF ANDROGEN RECEPTOR IN THE RAT SPINAL MOTONEURONS - IMMUNOHISTOCHEMICAL AND IMMUNOBLOTTING ANALYSES WITH MONOCLONAL-ANTIBODY

被引：22

作者：

MATSUURA, T

OGATA, A

DEMURA, T

MORIWAKA, F

TASHIRO, K

KOYANAGI, T

NAGASHIMA, K

机构：

[1] HOKKAIDO UNIV,SCH MED,DEPT UROL,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

[2] HOKKAIDO UNIV,SCH MED,DEPT PATHOL 2,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

来源：

NEUROSCIENCE LETTERS | 1993年 / 158卷 / 01期

关键词：

ANDROGEN RECEPTOR; SPINAL MOTONEURON; IMMUNOHISTOCHEMICAL STAIN; WESTERN BLOTTING; RAT; X-LINKED SPINAL AND BULBAR MUSCULAR ATROPHY;

D O I：

10.1016/0304-3940(93)90598-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Androgens play an important role in motoneuron growth, development and regeneration. We proved the existence of androgen receptor (AR) in the motoneurons of the rat spinal cord by the immunohistochemical stain and Western blotting. The possibility that AR protein in spinal cord is expressed in tissue-specific form is proposed, being different from other androgen-dependent tissues. AR abnormality in X-linked spinal and bulbar muscular atrophy (SBMA) among a variety of motor neuron diseases were reported recently. Our study may give some clue to the AR abnormality leading to the degeneration of motoneurons.

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页码：5 / 8

页数：4

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