IMMUNIZATION WITH WHOLE INACTIVATED VACCINE PROTECTS FROM INFECTION BY SIV GROWN IN HUMAN BUT NOT MACAQUE CELLS

被引：37

作者：

GOLDSTEIN, S

ELKINS, WR

LONDON, WT

HAHN, A

GOEKEN, R

MARTIN, JE

HIRSCH, VM

机构：

[1] NIAID,INFECT DIS LAB,IMMUNODEFICIENCY VIRUSES SECT,TWINBROOK FACIL 2,12441 PARKLAWN DR,ROCKVILLE,MD 20852

[2] GEORGETOWN UNIV,DEPT MICROBIOL,DIV MOLEC VIROL & IMMUNOL,ROCKVILLE,MD

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1994年 / 23卷 / 2-3期

关键词：

AIDS; ANTI-CELL ANTIBODIES; SIMIAN IMMUNODEFICIENCY VIRUS;

D O I：

10.1111/j.1600-0684.1994.tb00105.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Homologous SIV(sm) stocks were generated by passage of a macaque isolate of SIV(sm) (SIV(sm/E660)) in human CEM x 174 cells or macaque peripheral blood mononuclear cells. Macaques were immunized with whole inactivated SIV vaccine consisting of virus generated by transfection of CEM x 174 cells with the SIV(smH4) clone and were challenged with either cell-free stock. Only vaccinees challenged with virus generated in human cells were protected from infection. This confirms the species-specificity of whole inactivated vaccine-mediated protection.

引用

页码：75 / 82

页数：8

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