INTERFERON THERAPY IN DISSEMINATED RENAL-CELL CARCINOMA

被引：27

作者：

EDSMYR, F ^{[1
]}

ESPOSTI, PL ^{[1
]}

ANDERSSON, L ^{[1
]}

STEINECK, G ^{[1
]}

LAGERGREN, C ^{[1
]}

STRANDER, H ^{[1
]}

机构：

[1] KAROLINSKA HOSP, DEPT ONCOL, S-10401 STOCKHOLM 60, SWEDEN

来源：

RADIOTHERAPY AND ONCOLOGY | 1985年 / 4卷 / 01期

关键词：

D O I：

10.1016/S0167-8140(85)80058-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Twenty patients with pulmonary metastases of renal cell carcinomas were treated in a randomized study with either leukocyte interferon in daily doses of 3 .times. 106 IU i.m. or irradiation of both lungs in a calculated mean central dose of 10 Gy [gray] in 4 wk in combination with bleomycin and vincristine. Most patients had a short time to progression of their disease. Three patients in the interferon group had complete response (CR) and partial response (PR) and 1 patient in the other group had PR. The numbers of patients in both arms of the study are too small to allow any conclusions whether beneficial effects are more frequent in one group than in the other, but there is a more favorable tendency in the interferon group.

引用

页码：21 / 26

页数：6

共 12 条

[1] ANDERSON L, 1982, RENAL TUMORS, P661
[2] Cantell K, 1981, Methods Enzymol, V78, P29
[3] Cantell K, 1981, Methods Enzymol, V78, P499
[4] DEMAYER E, 1983, BIOL INTERFERON SYST
[5] FAIRLAMB DJ, 1981, CANCER-AM CANCER SOC, V47, P2102, DOI 10.1002/1097-0142(19810415)47:8<2102::AID-CNCR2820470833>3.0.CO
[6] 2-K
[7] MAGNUSSON K, 1983, ACTA MED SCAND, V213, P221
[8] MERIGAN TC, 1982, INTERFERONS, V25
[9] DESIGN AND ANALYSIS OF RANDOMIZED CLINICAL-TRIALS REQUIRING PROLONGED OBSERVATION OF EACH PATIENT .2. ANALYSIS AND EXAMPLES
PETO, R
PIKE, MC
ARMITAGE, P
BRESLOW, NE
COX, DR
HOWARD, SV
MANTEL, N
MCPHERSON, K
PETO, J
SMITH, PG
[J]. BRITISH JOURNAL OF CANCER, 1977, 35 (01) : 1 - 39
[10] QUESADA JR, 1983, CANCER RES, V43, P940

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