EVIDENCE FOR A DIPEPTIDE PORTER IN THE LYSOSOME MEMBRANE

被引:16
作者
BIRD, SJ [1 ]
LLOYD, JB [1 ]
机构
[1] UNIV KEELE,DEPT BIOL SCI,CELLULAR PHARMACOL RES GRP,KEELE ST5 5BG,STAFFS,ENGLAND
关键词
Dipeptide transport; Lysosome membrane;
D O I
10.1016/0005-2736(90)90353-P
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Small neutral dipeptides such as Gly-Gly are known to cross the lysosome membrane rapidly. The mode of dipeptide translocation was studied, using an osmotic-protection method. Results with dipeptide analogues, such as ω-amino aliphatic acids and taurine, indicated that dipeptides do not cross the rat liver lysosome membrane by unassisted diffusion. Using seven pairs of dipeptide stereoisomers, the penetration of the l-isomer was always found to be much more rapid than that of the d-analogue. It is concluded that the lysosome membrane contains a porter that recognizes and transports l-dipeptides. © 1990.
引用
收藏
页码:267 / 270
页数:4
相关论文
共 5 条
[1]   PERMEABILITY OF RAT-LIVER LYSOSOMES TO SUGARS - EVIDENCE FOR CARRIER-MEDIATED FACILITATED DIFFUSION [J].
DOCHERTY, K ;
BRENCHLEY, GV ;
HALES, CN .
BIOCHEMICAL JOURNAL, 1979, 178 (02) :361-366
[2]   SOLUTE TRANSLOCATION ACROSS THE MAMMALIAN LYSOSOME MEMBRANE [J].
FORSTER, S ;
LLOYD, JB .
BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 947 (03) :465-491
[3]   DIPEPTIDE HYDROLYSIS WITHIN INTACT LYSOSOMES IN-VITRO [J].
GOLDMAN, R .
FEBS LETTERS, 1973, 33 (02) :208-212
[4]   PASSIVE DIFFUSION OF NON-ELECTROLYTES ACROSS THE LYSOSOME MEMBRANE [J].
IVESON, GP ;
BIRD, SJ ;
LLOYD, JB .
BIOCHEMICAL JOURNAL, 1989, 261 (02) :451-456
[5]   STUDY OF PERMEABILITY OF LYSOSOMES TO AMINO ACIDS AND SMALL PEPTIDES [J].
LLOYD, JB .
BIOCHEMICAL JOURNAL, 1971, 121 (02) :245-&