EVIDENCE FOR A DIPEPTIDE PORTER IN THE LYSOSOME MEMBRANE

被引：16

作者：

BIRD, SJ ^{[1
]}

LLOYD, JB ^{[1
]}

机构：

[1] UNIV KEELE,DEPT BIOL SCI,CELLULAR PHARMACOL RES GRP,KEELE ST5 5BG,STAFFS,ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1024卷 / 02期

关键词：

Dipeptide transport; Lysosome membrane;

D O I：

10.1016/0005-2736(90)90353-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small neutral dipeptides such as Gly-Gly are known to cross the lysosome membrane rapidly. The mode of dipeptide translocation was studied, using an osmotic-protection method. Results with dipeptide analogues, such as ω-amino aliphatic acids and taurine, indicated that dipeptides do not cross the rat liver lysosome membrane by unassisted diffusion. Using seven pairs of dipeptide stereoisomers, the penetration of the l-isomer was always found to be much more rapid than that of the d-analogue. It is concluded that the lysosome membrane contains a porter that recognizes and transports l-dipeptides. © 1990.

引用

页码：267 / 270

页数：4

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