共 5 条
EVIDENCE FOR A DIPEPTIDE PORTER IN THE LYSOSOME MEMBRANE
被引:16
作者:
BIRD, SJ
[1
]
LLOYD, JB
[1
]
机构:
[1] UNIV KEELE,DEPT BIOL SCI,CELLULAR PHARMACOL RES GRP,KEELE ST5 5BG,STAFFS,ENGLAND
关键词:
Dipeptide transport;
Lysosome membrane;
D O I:
10.1016/0005-2736(90)90353-P
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Small neutral dipeptides such as Gly-Gly are known to cross the lysosome membrane rapidly. The mode of dipeptide translocation was studied, using an osmotic-protection method. Results with dipeptide analogues, such as ω-amino aliphatic acids and taurine, indicated that dipeptides do not cross the rat liver lysosome membrane by unassisted diffusion. Using seven pairs of dipeptide stereoisomers, the penetration of the l-isomer was always found to be much more rapid than that of the d-analogue. It is concluded that the lysosome membrane contains a porter that recognizes and transports l-dipeptides. © 1990.
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页码:267 / 270
页数:4
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