PHARMACOKINETICS OF ARTEETHER IN DOG

被引：15

作者：

BENAKIS, A ^{[1
]}

SCHOPFER, C ^{[1
]}

PARIS, M ^{[1
]}

PLESSAS, CT ^{[1
]}

KARAYANNAKOS, PE ^{[1
]}

DONDAS, I ^{[1
]}

KOTSARELIS, D ^{[1
]}

PLESSAS, ST ^{[1
]}

SKALKEAS, G ^{[1
]}

机构：

[1] UNIV ATHENS,SCH MED,EXPTL SURG & SURG RES LAB,ATHENS,GREECE

来源：

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 1991年 / 16卷 / 04期

关键词：

PHARMACOKINETICS; ARTEETHER; DOG; ANTIMALARIAL;

D O I：

10.1007/BF03189978

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A pharmacokinetic study has been conducted in six beagle dogs after i.m. administration of 25 mg/kg of arteether, a qinghaosu (artemisinin) derivative of high anti-malarial activity. Arteether plasma concentrations were measured during a 24 h period using HPLC with an electrochemical detector in the reductive mode. The pharmacokinetic parameters were established using an open two-compartment model. Results showed a relatively rapid absorption phase: T1/2ka was 0.300 +/- 0.096 h and a mean elimination half-life of 27.95 +/- 11.93 h. C(max) was 110 +/- 16 ng/ml, Cl(tot)/F was 1.69 +/- 0.34 ml/min and AUC was 2797 +/- 476 ng/ml/h.

引用

页码：325 / 328

页数：4

共 5 条

[1] HEPATIC-METABOLISM OF ARTEMISININ DRUGS .2. METABOLISM OF ARTEETHER IN RAT-LIVER CYTOSOL
LESKOVAC, V
THEOHARIDES, AD
[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1991, 99 (03): : 391 - 396
[2] ARTEMISININ (QINGHAOSU) - THE ROLE OF INTRACELLULAR HEMIN IN ITS MECHANISM OF ANTIMALARIAL ACTION
MESHNICK, SR
THOMAS, A
RANZ, A
XU, CM
PAN, HZ
[J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1991, 49 (02) : 181 - 190
[3] YANG SD, 1985, CHIN J CLIN PHARM, V1, P106
[4] Zhao K. C., 1990, Acta Pharmaceutica Sinica, V25, P147
[5] ZHAO KC, 1986, ACTA PHARMACOL SINIC, V21, P736

← 1 →