REPLICATION-DEFECTIVE MISSENSE MUTATIONS WITHIN THE TERMINAL PROTEIN AND SPACER INTRON REGIONS OF THE POLYMERASE GENE OF HUMAN HEPATITIS-B VIRUS

被引：10

作者：

FARUQI, AF ^{[1
]}

ROYCHOUDHURY, S ^{[1
]}

GREENBERG, R ^{[1
]}

ISRAEL, J ^{[1
]}

SHIH, C ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT BIOCHEM & BIOPHYS,PHILADELPHIA,PA 19104

来源：

VIROLOGY | 1991年 / 183卷 / 02期

关键词：

D O I：

10.1016/0042-6822(91)91007-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have analyzed 11 independent mutations located at various domains of the polymerase gene (pol) of human hepatitis B virus. Surprisingly, one of the two missense mutants within the spacer/intron region appears to be lethal. This result further defines the N-terminal limit of the reverse transcriptase domain. Alternatively, it suggests the potential existence of a novel domain with an unknown function. Two missense mutations within the terminal protein (TP) domain appear to be replication-defective as well, suggesting a functionally essential role of the TP domain in DNA replication. © 1991.

引用

页码：764 / 768

页数：5

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