ANTIBACTERIAL ACTIVITY OF TOTAROL AND ITS POTENTIATION

被引：100

作者：

KUBO, I

MUROI, H

HIMEJIMA, M

机构：

[1] Division of Entomology and Parasitology, College of Natural Resources, University of California, Berkeley

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 10期

关键词：

D O I：

10.1021/np50088a008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Antimicrobial activity of six diterpenoids isolated from the bark of Podocarpus nagi (Podocarpaceae) has been tested against twelve selected microorganisms. Totarol [1], the most abundant compound among the six, exhibited potent bactericidal activity only against Gram-positive bacteria, among which Propionibacterium acnes was the most senstitive bacterium. Totarol also showed strong activity against four other Gram-positive bacteria tested: Streptococcus mutans, Bacillus subtilis, Brevibacterium ammoniagenes, and Staphylococcus aureus (both penicillin-resistant and penicillin-susceptible strains). The bactericidal activity of totarol was enhanced when it was tested in combination with several other natural products. Noticeably, the activity of totarol against Sta. aureus was increased eightfold when tested in combination with 1/2MIC of anacardic acid [9]. The synergistic activity of anacardic acid caused the minimum bactericidal concentration (MBC) of totarol to be lowered from 1.56 to 0.2 mug/ml.

引用

页码：1436 / 1440

页数：5

共 14 条

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