A RATIONAL APPROACH TO THE NON-RESPONDING DEPRESSED PATIENT

被引:16
作者
DINAN, TG
机构
[1] Department of Psychological Medicine, St Bartholomew’s Hospital, London
关键词
LITHIUM AUGMENTATION; SSRIS; TREATMENT-RESISTANT DEPRESSION;
D O I
10.1097/00004850-199300840-00003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
At least 30% of patients with major depression fail to respond to conventional antidepressant medication, even when given adequate doses. Numerous factors have been implicated in treatment resistance including subclinical hypothyroidism, alcohol abuse, occult carcinoma, minor head injuries and the use of calcium channel blockers such as nifedipine. Lithium augmentation of traditional tricyclic antidepressants and selective serotonin re-uptake inhibitors such as fluoxetine are the most extensively investigated combinations used to treat non-responsive depression. Other strategies are also briefly discussed.
引用
收藏
页码:221 / 223
页数:3
相关论文
共 24 条
[1]  
BRIDGES PK, 1983, BRIT J PSYCHIAT, V42, P626
[2]   LITHIUM INDUCES RAPID RELIEF OF DEPRESSION IN TRICYCLIC ANTI-DEPRESSANT DRUG NON-RESPONDERS [J].
DEMONTIGNY, C ;
GRUNBERG, F ;
MAYER, A ;
DESCHENES, JP .
BRITISH JOURNAL OF PSYCHIATRY, 1981, 138 (MAR) :252-256
[3]   PATHOPHYSIOLOGY OF CHOLINOCEPTOR SUPERSENSITIVITY IN AFFECTIVE-DISORDERS [J].
DILSAVER, SC .
BIOLOGICAL PSYCHIATRY, 1986, 21 (8-9) :813-829
[4]   A COMPARISON OF ELECTROCONVULSIVE-THERAPY WITH A COMBINED LITHIUM AND TRICYCLIC COMBINATION AMONG DEPRESSED TRICYCLIC NONRESPONDERS [J].
DINAN, TG ;
BARRY, S .
ACTA PSYCHIATRICA SCANDINAVICA, 1989, 80 (01) :97-100
[5]   TREATMENT RESISTANCE OF DEPRESSION AFTER HEAD-INJURY - A PRELIMINARY-STUDY OF AMITRIPTYLINE RESPONSE [J].
DINAN, TG ;
MOBAYED, M .
ACTA PSYCHIATRICA SCANDINAVICA, 1992, 85 (04) :292-294
[6]  
DINAN TG, 1993, IN PRESS ACTA PSYCHI
[7]  
DINAN TG, 1988, IN PRESS INT CLIN PS, V6, P23
[8]   CALCIUM-CHANNEL BLOCKADE AND DEPRESSIVE-ILLNESS [J].
ECCLESTON, D ;
COLE, AJ .
BRITISH JOURNAL OF PSYCHIATRY, 1990, 156 :889-891
[9]  
GOODWIN FK, 1982, AM J PSYCHIAT, V139, P34
[10]  
GUSCOTT R, 1991, AM J PSYCHIAT, V148, P695