MITOCHONDRIAL-DNA VARIATION IN HUMAN-POPULATIONS AND IMPLICATIONS FOR DETECTION OF MITOCHONDRIAL-DNA MUTATIONS OF PATHOLOGICAL SIGNIFICANCE

被引:80
作者
TORRONI, A
WALLACE, DC
机构
[1] Department of Genetics and Molecular Medicine, Emory University School of Medicine, Atlanta, 30322, Georgia
关键词
D O I
10.1007/BF00763098
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Haplotype and phylogenetic analyses of ''normal'' mitochondrial DNAs (mtDNAs) have allowed a clarification of several controversial issues concerning the origin of humans, the time and colonization pattern of the various regions of the world, and the genetic relationships of modern human populations. More recently, the same type of analyses has also been applied to mtDNA disease studies. A review of these studies indicates that exhaustive screenings of ''normal'' mtDNA variation in all human populations associated with haplotype and phylogenetic analyses are essential if we are to understand the etiology of mitochondrial pathologies.
引用
收藏
页码:261 / 271
页数:11
相关论文
共 43 条
[1]  
Ammerman A.J., 1984, NEOLITHIC TRANSITION
[2]   SEQUENCE AND ORGANIZATION OF THE HUMAN MITOCHONDRIAL GENOME [J].
ANDERSON, S ;
BANKIER, AT ;
BARRELL, BG ;
DEBRUIJN, MHL ;
COULSON, AR ;
DROUIN, J ;
EPERON, IC ;
NIERLICH, DP ;
ROE, BA ;
SANGER, F ;
SCHREIER, PH ;
SMITH, AJH ;
STADEN, R ;
YOUNG, IG .
NATURE, 1981, 290 (5806) :457-465
[3]  
BALLINGER SW, 1992, GENETICS, V130, P139
[4]   MITOCHONDRIAL MUTATIONS MAY INCREASE OXIDATIVE STRESS - IMPLICATIONS FOR CARCINOGENESIS AND AGING [J].
BANDY, B ;
DAVISON, AJ .
FREE RADICAL BIOLOGY AND MEDICINE, 1990, 8 (06) :523-539
[5]  
Bar-Yosef O., 1992, MIDDLE PALEOLITHIC C, P261
[6]  
BARRANTES R, 1990, AM J HUM GENET, V46, P63
[7]   MODERN HUMANS IN THE LEVANT [J].
BARYOSEF, O ;
VANDERMEERSCH, B .
SCIENTIFIC AMERICAN, 1993, 268 (04) :94-100
[8]  
BLANC H, 1983, AM J HUM GENET, V35, P167
[9]   A TANDEM DUPLICATION IN THE D-LOOP OF HUMAN MITOCHONDRIAL-DNA IS ASSOCIATED WITH DELETIONS IN MITOCHONDRIAL MYOPATHIES [J].
BROCKINGTON, M ;
SWEENEY, MG ;
HAMMANS, SR ;
MORGANHUGHES, JA ;
HARDING, AE .
NATURE GENETICS, 1993, 4 (01) :67-71
[10]  
BROWN MD, 1992, GENETICS, V130, P163