INSULIN STIMULATES THE DEPHOSPHORYLATION AND ACTIVATION OF ACETYL-COA CARBOXYLASE

被引：96

作者：

WITTERS, LA ^{[1
]}

WATTS, TD ^{[1
]}

DANIELS, DL ^{[1
]}

EVANS, JL ^{[1
]}

机构：

[1] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT BIOCHEM,HANOVER,NH 03756

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1988年 / 85卷 / 15期

关键词：

D O I：

10.1073/pnas.85.15.5473

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：5473 / 5477

页数：5

共 32 条

[1] MECHANISMS INVOLVED IN THE SHORT-TERM REGULATION OF ACETYL-COA CARBOXYLASE BY INSULIN [J].

BORTHWICK, AC ;

EDGELL, NJ ;

DENTON, RM .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1986, 14 (03) :563-565

[2] EVIDENCE THAT INSULIN ACTIVATES FAT-CELL ACETYL-COA CARBOXYLASE BY INCREASED PHOSPHORYLATION AT A SPECIFIC SITE [J].

BROWNSEY, RW ;

DENTON, RM .

BIOCHEMICAL JOURNAL, 1982, 202 (01) :77-86

[3] ADRENALINE AND THE REGULATION OF ACETYL-COENZYME-A CARBOXYLASE IN RAT EPIDIDYMAL ADIPOSE-TISSUE - INACTIVATION OF THE ENZYME IS ASSOCIATED WITH PHOSPHORYLATION AND CAN BE REVERSED ON DEPHOSPHORYLATION [J].

BROWNSEY, RW ;

HUGHES, WA ;

DENTON, RM .

BIOCHEMICAL JOURNAL, 1979, 184 (01) :23-32

[4] A COMMON BICYCLIC PROTEIN-KINASE CASCADE INACTIVATES THE REGULATORY ENZYMES OF FATTY-ACID AND CHOLESTEROL-BIOSYNTHESIS [J].

CARLING, D ;

ZAMMIT, VA ;

HARDIE, DG .

FEBS LETTERS, 1987, 223 (02) :217-222

[5]

EVANS JA, 1988, IN PRESS ARCH BIOCH

[6] REGULATION OF MAMMALIAN ACETYL-COA CARBOXYLASE - LIMITED PROTEOLYSIS MIMICS DEPHOSPHORYLATION [J].

GUY, PS ;

HARDIE, DG .

FEBS LETTERS, 1981, 132 (01) :67-70

[7] BOTH INSULIN AND EPIDERMAL GROWTH-FACTOR STIMULATE LIPOGENESIS AND ACETYL-COA CARBOXYLASE ACTIVITY IN ISOLATED ADIPOCYTES - IMPORTANCE OF HOMOGENIZATION PROCEDURE IN AVOIDING ARTIFACTS IN ACETYL-COA CARBOXYLASE ASSAY [J].

HAYSTEAD, TAJ ;

HARDIE, DG .

BIOCHEMICAL JOURNAL, 1986, 234 (02) :279-284

[8] EVIDENCE THAT ACTIVATION OF ACETYL-COA CARBOXYLASE BY INSULIN IN ADIPOCYTES IS MEDIATED BY A LOW-MR EFFECTOR AND NOT BY INCREASED PHOSPHORYLATION [J].

HAYSTEAD, TAJ ;

HARDIE, DG .

BIOCHEMICAL JOURNAL, 1986, 240 (01) :99-106

[9] BOTH INSULIN AND EPIDERMAL GROWTH-FACTOR STIMULATE FATTY-ACID SYNTHESIS AND INCREASE PHOSPHORYLATION OF ACETYL-COA CARBOXYLASE AND ATP-CITRATE LYASE IN ISOLATED HEPATOCYTES [J].

HOLLAND, R ;

HARDIE, DG .

FEBS LETTERS, 1985, 181 (02) :308-312

[10] GLUCAGON INHIBITS FATTY-ACID SYNTHESIS IN ISOLATED HEPATOCYTES VIA PHOSPHORYLATION OF ACETYL-COA CARBOXYLASE BY CYCLIC-AMP-DEPENDENT PROTEIN-KINASE [J].

HOLLAND, R ;

WITTERS, LA ;

HARDIE, DG .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1984, 140 (02) :325-333

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