NEW BIOCATALYSTS FOR PEPTIDE-SYNTHESIS - GELS OF COPOLYMERIZED ACRYLIC DERIVATIVES OF ALPHA-CHYMOTRYPSIN AND POLYOXYETHYLENE

被引：21

作者：

FULCRAND, V ^{[1
]}

JACQUIER, R ^{[1
]}

LAZARO, R ^{[1
]}

VIALLEFONT, P ^{[1
]}

机构：

[1] UNIV MONTPELLIER SCI & TECH LANGUEDOC 2,CNRS,SYNTH & ETUD PHYSICOCHIM AMINOACIDES & PEPTIDES LAB,F-34095 MONTPELLIER 5,FRANCE

来源：

TETRAHEDRON | 1990年 / 46卷 / 11期

关键词：

D O I：

10.1016/S0040-4020(01)90526-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copolymers of acrylated derivatives of α-chymotrypsin and polyethylene glycol (PEG*) have been prepared and used as biocatalysts for the synthesis of model peptides in organic solvent. AcTyrLeuNH2 is quantitatively obtained even after a dozen of cycles. © 1990.

引用

收藏

页码：3909 / 3920

页数：12

相关论文

共 28 条

[1] ENZYMATIC PEPTIDE SYNTHESES IN ORGANIC-SOLVENT MEDIATED BY MODIFIED ALPHA-CHYMOTRYPSIN [J].

BABONNEAU, MT ;

JACQUIER, R ;

LAZARO, R ;

VIALLEFONT, P .

TETRAHEDRON LETTERS, 1989, 30 (21) :2787-2790

[2] 2K-P FRACTIONAL FACTORIAL DESIGNS .1. [J].

BOX, GE ;

HUNTER, JS .

TECHNOMETRICS, 1961, 3 (03) :311-&

[3] 2K-P FRACTIONAL FACTORIAL DESIGNS .2. [J].

BOX, GEP ;

HUNTER, JS .

TECHNOMETRICS, 1961, 3 (04) :449-&

[4]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[5] GENERAL-ASPECTS AND OPTIMIZATION OF ENANTIOSELECTIVE BIOCATALYSIS IN ORGANIC-SOLVENTS - THE USE OF LIPASES [J].

CHEN, CS ;

SIH, CJ .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1989, 28 (06) :695-707

[6] POLYETHERS .10. ENDGROUPS IN POLYETHYLENE OXIDE [J].

EBERT, PE ;

PRICE, CC .

JOURNAL OF POLYMER SCIENCE, 1960, 46 (148) :455-474

[7]

FERGANCIC A, 1988, BIOTECHNOL LETT, V10, P101

[8] KINETICS AND SPECIFICITY OF SERINE PROTEASES IN PEPTIDE-SYNTHESIS CATALYZED IN ORGANIC-SOLVENTS [J].

GAERTNER, H ;

PUIGSERVER, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1989, 181 (01) :207-213

[9] PEPTIDE-SYNTHESIS CATALYZED BY POLYETHYLENE GLYCOL-MODIFIED CHYMOTRYPSIN IN ORGANIC-SOLVENTS [J].

GAERTNER, HF ;

PUIGSERVER, AJ .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1988, 3 (02) :130-137

[10] DETERMINATION OF FREE AMINO GROUPS IN PROTEINS BY TRINITROBENZENESULFONIC ACID [J].

HABEEB, AFS .

ANALYTICAL BIOCHEMISTRY, 1966, 14 (03) :328-&