INVERSION OF CHROMOSOME-16 AND BONE-MARROW EOSINOPHILIA IN A MYELOMONOCYTIC TRANSFORMATION OF CHRONIC MYELOID-LEUKEMIA

被引：29

作者：

ASOU, N

SANADA, I

TANAKA, K

HIDAKA, M

SUZUSHIMA, H

MATSUZAKI, H

KAWANO, F

TAKATSUKI, K

机构：

[1] KUMAMOTO CITY HOSP, 1-5 NINOMARU, KUMAMOTO 860, JAPAN

[2] KUMAMOTO UNIV, SCH MED, DEPT INTERNAL MED 2, KUMAMOTO 860, JAPAN

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 61卷 / 02期

关键词：

D O I：

10.1016/0165-4608(92)90086-N

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a case of chronic myeloid leukemia (CML) in myelomonocytic transformation associated with bone marrow (BM) eosinophilia. At diagnosis, all BM cells showed a Ph chromosome. At the time of blastic phase, more than 50% of Ph+ cells had a pericentric inversion of chromosome 16, inv(16)(p13q22). This case confirms that blastic transformation of CML can involve any committed progenitor, and myelomonocytic leukemia with BM eosinophilia is specifically associated with rearrangement of chromosome 16 at band p13 and q22.

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页码：197 / 200

页数：4

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